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Role of cell–cell adhesion complexes in embryonic stem cell biology

15 Jun 2014

Abstract excerpt

Pluripotent embryonic stem cells (ESCs) can self-renew or differentiate into any cell type within an organism. Here, we focus on the roles of cadherins and catenins - their cytoplasmic scaffold proteins - in the fate, maintenance and differentiation of mammalian ESCs. E-cadherin is a master stem cell regulator that is required for both mouse ESC (mESC) maintenance and differentiation. E-cadherin interacts with...

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PMID: 24931943
DOI: 10.1242/jcs.146720

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