Article

ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling

2019-09-09

Abstract excerpt

ADNP (Activity Dependent Neuroprotective Protein) is proposed as a neuroprotective protein whose aberrant expression has been frequently linked to neural developmental disorders, including the Helsmoortel-Van der Aa syndrome. However, its role in neural development and pathology remains unclear. Using mESC (mouse embryonic stem cell) directional neural differentiation as a model, we show that ADNP is required for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6b18e69-eaee-52ec-8ae7-878a2100d8f3
DOI: 10.1101/761064

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ADNP promotes neural differentiation by modulating Wnt/β-catenin signalingDOI 10.1101/761064Read

ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.Semantic proximity Read

ADNP dysregulates methylation and mitochondrial gene expression in the cerebellum of a Helsmoortel–Van der Aa syndrome autopsy caseSemantic proximity Read

Cloning and characterization of the human activity-dependent neuroprotective protein.Semantic proximity Read

Novel Evolutionary-conserved Role for the Activity-dependent Neuroprotective Protein (ADNP) Family That Is Important for ErythropoiesisSemantic proximity Read

Silencing of the ADNP‐family member, ADNP2, results in changes in cellular viability under oxidative stressSemantic proximity Read

Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome.Semantic proximity Read

Roles of Armadillo, a Drosophila catenin, during central nervous system development.Semantic proximity Read

Transcriptomic Analysis Uncovers an Unfolded Protein Response in ADNP Syndrome.Semantic proximity Read

An Adnp frameshift variant disrupts Wnt signalling inducing chromatocytoskeletal defects and autism-related behaviour in male mice.Semantic proximity Read

Activity-dependent Neuroprotective Protein Constitutes a Novel Element in the SWI/SNF Chromatin Remodeling ComplexSemantic proximity Read

Disruption of ADNP-KDM1A-GTF2I complex drives neural differentiation imbalance in Helsmoortel-Van der Aa syndromeSemantic proximity Read

14-3-3 shuttles Activity-dependent neuroprotective protein to the cytoplasm to promote appropriate neuronal morphogenesis, cortical connectivity and calcium signalingSemantic proximity Read