Article
Retinoic acid-dependent signaling pathways and lineage events in the developing mouse spinal cord.
PloS one - 1 Jan 2012
Paschaki Marie, Lin Song-Chang, Wong Rebecca Lee Yean, Finnell Richard H, Dollé Pascal, Niederreither Karen
Abstract excerpt
Studies in avian models have demonstrated an involvement of retinoid signaling in early neural tube patterning. The roles of this signaling pathway at later stages of spinal cord development are only partly characterized. Here we use Raldh2-null mouse mutants rescued from early embryonic lethality to study the consequences of lack of endogenous retinoic acid (RA) in the differentiating spinal cord. Mid-gestation...
Topics
- Aldehyde Oxidoreductases
- Animals
- Cell Differentiation
- Cell Lineage
- Fibroblast Growth Factors
- Ganglia, Spinal
- Intermediate Filament Proteins
- Mice
- Mice, Transgenic
- Mutation
- Nerve Tissue Proteins
- Nestin
- Neural Stem Cells