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Article

Developmental consequences of abnormal folate transport during murine heart morphogenesis

25 Jun 2004

Abstract excerpt

BACKGROUND: Folic acid is essential for the synthesis of nucleotides and methyl transfer reactions. Folic acid-binding protein one (Folbp1) is the primary mediator of folic acid transport into murine cells. Folbp1 knockout mouse embryos die in utero with multiple malformations, including severe congenital heart defects (CHDs). Although maternal folate supplementation is believed to prevent human conotruncal heart...

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PMID: 15259034
DOI: 10.1002/bdra.20043

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