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Article

Cardiovascular abnormalities in <i>Folr1</i> knockout mice and folate rescue

7 Feb 2007

Abstract excerpt

BACKGROUND: Periconceptional folic acid supplementation is widely believed to aid in the prevention of neural tube defects (NTDs), orofacial clefts, and congenital heart defects. Folate-binding proteins or receptors serve to bind folic acid and 5-methyltetrahydrofolate, representing one of the two major mechanisms of cellular folate uptake. METHODS: We herein describe abnormal cardiovascular development in mouse...

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PMID: 17286298
DOI: 10.1002/bdra.20347

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