Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Precise Dose of Folic Acid Supplementation Is Essential for Embryonic Heart Development in Zebrafish

26 Dec 2021

Abstract excerpt

Folic acid, one of the 13 essential vitamins, plays an important role in cardiovascular development. Mutations in folic acid synthesis gene 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with the occurrence of congenital heart disease. However, the mechanisms underlying the regulation of cardiac development by mthfr gene are poorly understood. Here, we exposed zebrafish embryos to excessive folate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Congenital Heart Disease Studies
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35053026
DOI: 10.3390/biology11010028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Precise Dose of Folic Acid Supplementation Is Essential for Embryonic Heart Development in ZebrafishPMID 35053026Read ↗

Folic Acid Exerts Dose-Dependent Biphasic Effects on Cardiac Development of Zebrafish EmbryosSemantic proximity Read ↗

Disruption of the folate pathway in zebrafish causes developmental defectsSemantic proximity Read ↗

Folate, Homocysteine and the Cardiac Neural CrestSemantic proximity Read ↗

Cardiovascular abnormalities in <i>Folr1</i> knockout mice and folate rescueSemantic proximity Read ↗

First‐Trimester Maternal Folic Acid Supplementation Reduced Risks of Severe and Most Congenital Heart Diseases in Offspring: A Large Case‐Control StudySemantic proximity Read ↗

Maternal Serum Folate During Pregnancy and Congenital Heart Disease in OffspringSemantic proximity Read ↗

Maternal iron deficiency perturbs embryonic cardiovascular developmentSemantic proximity Read ↗

Congenital Heart Disease and Genetic Changes in Folate/Methionine Cycles.Semantic proximity Read ↗

Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in miceSemantic proximity Read ↗

Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in miceSemantic proximity Read ↗

Maternal folic acid over-supplementation impairs cardiac function in mice offspring by inhibiting SOD1 expressionSemantic proximity Read ↗

Risk of congenital heart defects is influenced by genetic variation in folate metabolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.