Article
Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development.
Nature genetics - 1 Oct 1999
Piedrahita J A, Oetama B, Bennett G D, van Waes J, Kamen B A, Richardson J, Lacey S W, Anderson R G, Finnell R H
Abstract excerpt
Periconceptional folic acid supplementation reduces the occurrence of several human congenital malformations, including craniofacial, heart and neural tube defects. Although the underlying mechanism is unknown, there may be a maternal-to-fetal folate-transport defect or an inherent fetal biochemical disorder that is neutralized by supplementation. Previous experiments have identified a folate-binding protein...
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