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Article

Maternal folate deficiency affects proliferation, but not apoptosis, in embryonic mouse heart.

The Journal of nutrition - 1 Jul 2006

Li Deqiang, Rozen Rima

Abstract excerpt

Low dietary folate and deficiency of methylenetetrahydrofolate reductase (Mthfr) were reported to increase the risk for congenital heart defects, but contributory mechanisms have not been elucidated. Because low folate and absent MTHFR activity were shown to affect proliferation and apoptosis in developing neural tissue, we examined these processes in the myocardium of embryos from Mthfr +/+ and Mthfr +/- mice...

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Source

Identifiers

PMID: 16772436
DOI: 10.1093/jn/136.7.1774

Genes

FADD
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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