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Maternal folic acid over-supplementation impairs cardiac function in mice offspring by inhibiting SOD1 expression

8 Sept 2024

Abstract excerpt

AIMS: Folic acid (FA) supplementation during pregnancy aims to protect foetal development. However, maternal over-supplementation of FA has been demonstrated to cause metabolic dysfunction and increase the risk of autism, retinoblastoma, and respiratory illness in the offspring. Moreover, FA supplementation reduces the risk of congenital heart disease. However, little is known about its possible adverse effects...

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PMID: 39253986
DOI: 10.1093/cvr/cvae203

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