Article
Embryonic development of folate binding protein-1 (Folbp1) knockout mice: Effects of the chemical form, dose, and timing of maternal folate supplementation.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 2004
Spiegelstein Ofer, Mitchell Laura E, Merriweather Michelle Y, Wicker Ned J, Zhang Qiang, Lammer Edward J, Finnell Richard H
Abstract excerpt
Inactivation of folate binding protein-1 (Folbp1) adversely impacts murine embryonic development, as nullizygous embryos (Folbp1(-/-)) die in utero. Administration of folinic acid (N5-formyl-tetrahydrofolate) to Folbp1-deficient dams before and throughout gestation rescues the majority of embryos from premature death; however, a portion of surviving embryos develop structural malformations, including neural tube...
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