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Article

Disruption of the folate pathway in zebrafish causes developmental defects

5 Apr 2012

Abstract excerpt

BACKGROUND: Folic acid supplementation reduces the risk of neural tube defects and congenital heart defects. The biological mechanisms through which folate prevents birth defects are not well understood. We explore the use of zebrafish as a model system to investigate the role of folate metabolism during development. RESULTS: We first identified zebrafish orthologs of 12 human folate metabolic genes. RT-PCR and...

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PMID: 22480165
DOI: 10.1186/1471-213x-12-12

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