Article
Downregulation of 14-3-3sigma in ovary, prostate and endometrial carcinomas is associated with CpG island methylation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2005
Mhawech Paulette, Benz Ana, Cerato Christelle, Greloz Vincent, Assaly Mounia, Desmond Julian C, Koeffler H Phillip, Lodygin Dimitri, Hermeking Heiko, Herrmann François, Schwaller Juerg
Abstract excerpt
The 14-3-3sigma inhibitor of cell cycle progression has been shown to be target of epigenetic deregulation in many forms of human cancers; however, its role in urological and gynecological cancers has not been studied. Here, we have analyzed the expression of 14-3-3sigma, wild-type p53 and mutated p53 in over 300 cases of the most common cancers occurring in the urological and gynecological tracts and its normal...
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