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Article

Inactivation of the 14-3-3 sigma gene is associated with 5' CpG island hypermethylation in human cancers.

Cancer research - 15 Aug 2000

Suzuki H, Itoh F, Toyota M, Kikuchi T, Kakiuchi H, Imai K

Abstract excerpt

The cell cycle checkpoint plays an important role in maintaining the integrity of cells. Recently, one of the 14-3-3 protein family members, 14-3-3sigma, was shown to be regulated by p53 and to play a role in the G2-M-phase checkpoint. To determine whether 14-3-3sigma is inactivated in human cancers, the methylation status of the 5' region of 14-3-3sigma was investigated in a series of gastric, colorectal, and...

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PMID: 10969776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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Inactivation of the 14-3-3 sigma gene is associated with 5' CpG island hypermethylation in human cancers.PMID 10969776Read ↗

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