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14-3-3σ Positively Regulates p53 and Suppresses Tumor Growth

29 Sept 2003

Abstract excerpt

The 14-3-3 sigma (sigma) protein, a negative regulator of the cell cycle, is a human mammary epithelium-specific marker that is downregulated in transformed mammary carcinoma cells. It has also been identified as a p53-inducible gene product involved in cell cycle checkpoint control after DNA damage. Although 14-3-3 sigma is linked to p53-regulated cell cycle checkpoint control, detailed mechanisms of how cell...

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PMID: 14517281
DOI: 10.1128/mcb.23.20.7096-7107.2003

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14-3-3σ Positively Regulates p53 and Suppresses Tumor GrowthPMID 14517281Read ↗

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