Article
The tumor suppressor gene 14-3-3 sigma is commonly methylated in normal and malignant lymphoid cells.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2003
Bhatia Kishor, Siraj Abdul K, Hussain Azhar, Bu Rong, Gutiérrez Marina I
Abstract excerpt
14-3-3 sigma/Stratifin was first identified as an epithelial cell antigen (HME-1) exclusively expressed in epithelia. However, the functional role of sigma in cell proliferation and apoptosis would suggest that this protein could be relevant to the regulation of growth and differentiation of multiple cell types. Recent evidence demonstrates that sigma acts as a tumor suppressor gene that is inactivated by...
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