Article
Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.
Molecular & cellular proteomics : MCP - 1 Jun 2005
Benzinger Anne, Muster Nemone, Koch Heike B, Yates John R, Hermeking Heiko
Abstract excerpt
To comprehensively identify proteins interacting with 14-3-3 sigma in vivo, tandem affinity purification and the multidimensional protein identification technology were combined to characterize 117 proteins associated with 14-3-3 sigma in human cells. The majority of identified proteins contained one or several phosphorylatable 14-3-3-binding sites indicating a potential direct interaction with 14-3-3 sigma. 25...
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