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Article

Promoter methylation of IGFBP-3 and p53 expression in ovarian endometrioid carcinoma

1 Dec 2009

Abstract excerpt

BACKGROUND: Insulin-like growth factor binding protein (IGFBP-3) is an antiproliferative, pro-apoptotic and invasion suppressor protein which is transcriptionally regulated by p53. Promoter methylation has been linked to gene silencing and cancer progression. We studied the correlation between IGFBP-3 and p53 expression as well as IGFBP-3 promoter methylation in ovarian endometrioid carcinoma (OEC) by...

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Share to Epigenetics and DNA Methylation
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PMID: 20003326
DOI: 10.1186/1476-4598-8-120

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