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Article

p53 upregulation is a frequent response to deficiency of cell-essential genes.

PloS one - 31 Dec 2010

Danilova Nadia, Kumagai Asako, Lin Jenny

Abstract excerpt

BACKGROUND: The role of p53 in the prevention of development of embryos damaged by genotoxic factors is well recognized. However, whether p53 plays an analogous role in preventing birth defects from genetic mutations remains an unanswered question. Genetic screens for mutations affecting development show that only a fraction of developmentally lethal mutations leads to specific phenotypes while the majority...

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Identifiers

PMID: 21209837
DOI: 10.1371/journal.pone.0015938
PMCID: PMC3013139

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Source receipt: pubmed, retrieved 7 Sept 2026.

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