Article
A systematic genome-wide analysis of zebrafish protein-coding gene function.
Nature - 25 Apr 2013
Kettleborough Ross N W, Busch-Nentwich Elisabeth M, Harvey Steven A, Dooley Christopher M, de Bruijn Ewart, van Eeden Freek, Sealy Ian, White Richard J, Herd Colin, Nijman Isaac J, Fényes Fruzsina, Mehroke Selina, Scahill Catherine, Gibbons Richard, Wali Neha, Carruthers Samantha, Hall Amanda, Yen Jennifer, Cuppen Edwin, Stemple Derek L
Abstract excerpt
Since the publication of the human reference genome, the identities of specific genes associated with human diseases are being discovered at a rapid rate. A central problem is that the biological activity of these genes is often unclear. Detailed investigations in model vertebrate organisms, typically mice, have been essential for understanding the activities of many orthologues of these disease-associated genes....
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