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Article

p53 Targets Simian Virus 40 Large T Antigen for Acetylation by CBP

14 Jul 2004

Abstract excerpt

Simian virus 40 (SV40) large T antigen (T Ag) interacts with the tumor suppressor p53 and the transcriptional coactivators CBP and p300. Binding of these cellular proteins in a ternary complex has been implicated in T Ag-mediated transformation. It has been suggested that the ability of CBP/p300 to modulate p53 function underlies p53's regulation of cell proliferation and tumorigenesis. In this study, we provide...

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Identifiers

PMID: 15254196
DOI: 10.1128/jvi.78.15.8245-8253.2004

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