Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p300 regulates p63 transcriptional activity.

The Journal of biological chemistry - 26 Aug 2005

MacPartlin Mary, Zeng Shelya, Lee Hunjoo, Stauffer Daniel, Jin Yetao, Thayer Mathew, Lu Hua

Abstract excerpt

The transcriptional co-activator p300 has been reported to regulate the tumor suppressor p53 and its ortholog p73. Here we describe a study showing that this coactivator also regulates the transcriptional function of p63. p300 bound to the N-terminal domain of p63gamma, and p63gamma bound to the N terminus of p300 in vitro and in cells. p300, but not its acetylase-defective mutant AT2, stimulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Cyclin-Dependent Kinase Inhibitor p21
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione Transferase

Share to Histidine

Share to Immunoprecipitation

Share to Phosphoproteins

Share to Transcriptional Activation

Source

Identifiers

PMID: 15965232
DOI: 10.1074/jbc.M503352200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p300 regulates p63 transcriptional activity.PMID 15965232Read ↗

p63: A Master Regulator at the Crossroads Between Development, Senescence, Aging, and CancerSemantic proximity Read ↗

p300 does not require its acetylase activity to stimulate p73 function.Semantic proximity Read ↗

p73gamma transactivates the p21 promoter through preferential interaction with the p300/CBP-associated factor in human prostate cancer cells.Semantic proximity Read ↗

p63-related signaling at a glanceSemantic proximity Read ↗

A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism.Semantic proximity Read ↗

Life and death of transcriptional co-activator p300Semantic proximity Read ↗

The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome SystemSemantic proximity Read ↗

p300/CBP proteins: HATs for transcriptional bridges and scaffoldsSemantic proximity Read ↗

The p53-homologue p63 may promote thyroid cancer progression.Semantic proximity Read ↗

Identification and functional characterization of two new transcriptional variants of the human p63 geneSemantic proximity Read ↗

DNA-Binding and Transactivation Activities Are Essential for TAp63 Protein DegradationSemantic proximity Read ↗

Dysregulation of the p300/CBP histone acetyltransferases in human cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.