Article
Binding of p300/CBP co-activators by polyoma large T antigen.
The Journal of biological chemistry - 7 Sept 2001
Cho S, Tian Y, Benjamin T L
Abstract excerpt
Small DNA tumor viruses such as simian virus 40 (SV40) and polyomavirus (Py) take advantage of host cell proteins to transcribe and replicate their DNA. Interactions between the viral T antigens and host proteins result in cell transformation and tumor induction. Large T antigen of SV40 interacts with p53, pRb/p107/p130 family members, and the cyclic AMP-responsive element-binding protein (CREB)-binding protein...
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