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Article

Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism.

The Journal of biological chemistry - 17 Sept 2004

Koh Ho-Jin, Lee Su-Min, Son Byung-Gap, Lee Soh-Hyun, Ryoo Zae Young, Chang Kyu-Tae, Park Jeen-Woo, Park Dong-Chan, Song Byoung J, Veech Richard L, Song Hebok, Huh Tae-Lin

Abstract excerpt

NADPH is an essential cofactor for many enzymatic reactions including glutathione metabolism and fat and cholesterol biosynthesis. We have reported recently an important role for mitochondrial NADP(+)-dependent isocitrate dehydrogenase in cellular defense against oxidative damage by providing NADPH needed for the regeneration of reduced glutathione. However, the role of cytosolic NADP(+)-dependent isocitrate...

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PMID: 15254034
DOI: 10.1074/jbc.M402260200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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