Expression and gene disruption analysis of the isocitrate dehydrogenase family in yeast.

doi:10.1021/bi9605189

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Article

Expression and gene disruption analysis of the isocitrate dehydrogenase family in yeast.

Biochemistry - 18 Jun 1996

Zhao W N, McAlister-Henn L

Abstract excerpt

Mammalian and yeast cells contain three isozymes of isocitrate dehydrogenase: mitochondrial NAD- and NADP-specific enzymes and a cytosolic NADP-specific enzyme. Independent metabolic functions of these enzymes in Saccharomyces cerevisiae were examined by analyses of expression and of phenotypes displayed by mutants containing all possible combinations of isozyme gene disruptions. All three isocitrate...

Topics

Acetates
Animals
Cytosol
Ethanol
Gene Expression
Genes, Fungal
Glucose
Isocitrate Dehydrogenase
Isoenzymes
Mammals
Mitochondria
Multigene Family
NAD
NADP
Phenotype
Saccharomyces cerevisiae
Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 8672488
DOI: 10.1021/bi9605189

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