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Article

Txnip balances metabolic and growth signaling via PTEN disulfide reduction.

Proceedings of the National Academy of Sciences of the United States of America - 11 Mar 2008

Hui Simon T Y, Andres Allen M, Miller Amber K, Spann Nathanael J, Potter Douglas W, Post Noah M, Chen Amelia Z, Sachithanantham Sowbarnika, Jung Dae Young, Kim Jason K, Davis Roger A

Abstract excerpt

Thioredoxin-interacting protein (Txnip) inhibits thioredoxin NADPH-dependent reduction of protein disulfides. Total Txnip knockout (TKO) mice adapted inappropriately to prolonged fasting by shifting fuel dependence of skeletal muscle and heart from fat and ketone bodies to glucose. TKO mice exhib...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 18322014
DOI: 10.1073/pnas.0800293105
PMCID: PMC2268825

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18322014-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Txnip balances metabolic and growth signaling via PTEN disulfide reduction.PMID 18322014Read ↗

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