Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates.

The Journal of biological chemistry - 31 Aug 2007

Yang Shu Yuan, Fugmann Sebastian D, Gramlich Hillary S, Schatz David G

Abstract excerpt

The molecular features that allow activation-induced cytidine deaminase (AID) to target Ig and certain non-Ig genes are not understood, although transcription has been implicated as one important parameter. We explored this issue by testing the mutability of a non-Ig transcription cassette in Ig and non-Ig loci of the chicken B cell line DT40. The cassette did not act as a stable long term mutation target but was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chickens

Share to Cytidine Deaminase

Share to Immunoglobulins

Share to Mutagenesis, Insertional

Share to Substrate Specificity

Share to Transcription, Genetic

Source

Identifiers

PMID: 17613522
DOI: 10.1074/jbc.M704231200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates.PMID 17613522Read ↗

Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.Semantic proximity Read ↗

Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate.Semantic proximity Read ↗

Targeting of AID-mediated sequence diversification to immunoglobulin genes.Semantic proximity Read ↗

Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion.Semantic proximity Read ↗

Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.Semantic proximity Read ↗

AID-initiated purposeful mutations in immunoglobulin genes.Semantic proximity Read ↗

A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.Semantic proximity Read ↗

Activation-induced cytidine deaminase structure and functions: a species comparative view.Semantic proximity Read ↗

Immunoglobulin gene conversion or hypermutation: that's the question.Semantic proximity Read ↗

AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene.Semantic proximity Read ↗

Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID‐mediated deoxycytidine deaminationSemantic proximity Read ↗

Why does somatic hypermutation by AID require transcription of its target genes?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.