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Article

Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin.

The Biochemical journal - 1 Nov 2004

Bourges Ingrid, Ramus Claire, Mousson de Camaret Bénédicte, Beugnot Réjane, Remacle Claire, Cardol Pierre, Hofhaus Götz, Issartel Jean-Paul

Abstract excerpt

Mitochondria-encoded ND (NADH dehydrogenase) subunits, as components of the hydrophobic part of complex I, are essential for NADH:ubiquinone oxidoreductase activity. Mutations or lack of expression of these subunits have significant pathogenic consequences in humans. However, the way these events affect complex I assembly is poorly documented. To understand the effects of particular mutations in ND subunits on...

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Identifiers

PMID: 15250827
DOI: 10.1042/BJ20040256
PMCID: PMC1133742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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