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Article

Human clinical mutations in mitochondrially encoded subunits of Complex I can be successfully modeled in E. coli.

Mitochondrion - 1 May 2022

Zhang Fang, Dang Quynh-Chi L, Vik Steven B

Abstract excerpt

Respiratory Complex I is the site of a large fraction of the mutations that appear to cause mitochondrial disease. Seven of its subunits are mitochondrially encoded, and therefore, such mutants are particularly difficult to construct in cell-culture model systems. We have selected 13 human clinical mutations found in ND2, ND3, ND4, ND4L, ND5 and ND6 that are generally found at subunit interfaces, and not in...

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Identifiers

PMID: 35306226
DOI: 10.1016/j.mito.2022.03.001
PMCID: PMC9035099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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