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Article

Mitochondrial genetic control of assembly and function of complex I in mammalian cells.

Journal of bioenergetics and biomembranes - 1 Jun 2001

Chomyn A

Abstract excerpt

Sixteen years ago, we demonstrated, by immunological and biochemical approaches, that seven subunits of complex I are encoded in mitochondrial DNA (mtDNA) and synthesized on mitochondrial ribosomes in mammalian cells. More recently, we carried out a biochemical, molecular, and cellular analysis of a mutation in the gene for one of these subunits, ND4, that causes Leber's hereditary optic neuropathy (LHON). We...

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Share to DNA, Mitochondrial
Share to Electron Transport Complex I
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NADH, NADPH Oxidoreductases

Share to Optic Atrophy, Hereditary, Leber

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Source

Identifiers

PMID: 11695835
DOI: 10.1023/a:1010791204961

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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