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Article

Human mitochondrial complex I assembly is mediated by NDUFAF1.

The FEBS journal - 1 Oct 2005

Vogel Rutger O, Janssen Rolf J R J, Ugalde Cristina, Grovenstein Melissa, Huijbens Richard J, Visch Henk-Jan, van den Heuvel Lambert P, Willems Peter H, Zeviani Massimo, Smeitink Jan A M, Nijtmans Leo G J

Abstract excerpt

Complex I (NADH:ubiquinone oxidoreductase) is the largest multiprotein enzyme of the oxidative phosphorylation system. Its assembly in human cells is poorly understood and no proteins assisting this process have yet been described. A good candidate is NDUFAF1, the human homologue of Neurospora crassa complex I chaperone CIA30. Here, we demonstrate that NDUFAF1 is a mitochondrial protein that is involved in the...

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Source

Identifiers

PMID: 16218961
DOI: 10.1111/j.1742-4658.2005.04928.x

Genes

NDUFAF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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