Article
A small protein coded within the mitochondrial canonical gene nd4 regulates mitochondrial bioenergetics
18 May 2023
Abstract excerpt
BACKGROUND: Mitochondria have a central role in cellular functions, aging, and in certain diseases. They possess their own genome, a vestige of their bacterial ancestor. Over the course of evolution, most of the genes of the ancestor have been lost or transferred to the nucleus. In humans, the mtDNA is a very small circular molecule with a functional repertoire limited to only 37 genes. Its extremely compact...
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