Article
Nuclear genes of human complex I of the mitochondrial electron transport chain: state of the art.
Human molecular genetics - 1 Jan 1998
Smeitink J A, Loeffen J L, Triepels R H, Smeets R J, Trijbels J M, van den Heuvel L P
Abstract excerpt
The mitochondrial electron transport chain (mtETC) consists of four multi-subunit enzyme complexes. Complex I or NADH:ubiquinone oxidoreductase, the largest mtETC multisubunit complex, consists of approximately 41 subunits. Seven of these subunits are encoded by the mitochondrial genome, the remainder by the nuclear genome. Among the mitochondriocytopathies, complex I deficiencies are encountered frequently....
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