Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2016

Lim Sze Chern, Hroudová Jana, Van Bergen Nicole J, Lopez Sanchez M Isabel G, Trounce Ian A, McKenzie Matthew

Abstract excerpt

Mitochondrial complex I (NADH:ubiquinone oxidoreductase) must be assembled precisely from 45 protein subunits for it to function correctly. One of its mitochondrial DNA (mtDNA) encoded subunits, ND1, is incorporated during the early stages of complex I assembly. However, little is known about how mutations in ND1 affect this assembly process. We found that in human 143B cybrid cells carrying a homoplasmic MT-ND1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Mutation

Share to NADH Dehydrogenase

Share to Transcriptome

Source

Identifiers

PMID: 26929434
DOI: 10.1096/fj.201500137R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly.PMID 26929434Read ↗

Early complex I assembly defects result in rapid turnover of the ND1 subunit.Semantic proximity Read ↗

Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV.Semantic proximity Read ↗

Mutation m.3395A > G in MT-ND1 leads to variable pathologic manifestations.Semantic proximity Read ↗

Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency.Semantic proximity Read ↗

An RMND1 Mutation causes encephalopathy associated with multiple oxidative phosphorylation complex deficiencies and a mitochondrial translation defect.Semantic proximity Read ↗

Mitochondrial complex I deficiency of nuclear origin II. Non-structural genes.Semantic proximity Read ↗

Human mitochondrial complex I assembly is mediated by NDUFAF1.Semantic proximity Read ↗

Unravelling the Effects of the Mutation m.3571insC/MT-ND1 on Respiratory Complexes Structural Organization.Semantic proximity Read ↗

An update on complex I assembly: the assembly of players.Semantic proximity Read ↗

Mitochondrial genetic control of assembly and function of complex I in mammalian cells.Semantic proximity Read ↗

Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression.Semantic proximity Read ↗

Assembly defects induce oxidative stress in inherited mitochondrial complex I deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.