Studies of the RB1 gene and the p53 gene in human osteosarcomas.

doi:10.3109/08880019209018328

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Article

Studies of the RB1 gene and the p53 gene in human osteosarcomas.

Pediatric hematology and oncology - 1 Jan 2000

Scholz R B, Kabisch H, Weber B, Röser K, Delling G, Winkler K

Abstract excerpt

We analyzed 14 native osteosarcoma tissue samples for alterations of the tumor suppressor genes RB1 and p53 on the DNA level, and as far as possible, the RNA level. Southern blot analyses concerning both tumor suppressor genes were carried out in all osteosarcomas. In two cases we could demonstra...

Topics

Bone Neoplasms
DNA Mutational Analysis
DNA, Neoplasm
Female
Gene Expression Regulation, Neoplastic
Gene Rearrangement
Genes, Retinoblastoma
Genes, p53
Genetic Predisposition to Disease
Humans
Male
Mutation
Osteosarcoma
RNA, Messenger
RNA, Neoplasm

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