Article
Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene.
Oncogene - 1 Sept 1990
Stratton M R, Moss S, Warren W, Patterson H, Clark J, Fisher C, Fletcher C D, Ball A, Thomas M, Gusterson B A
Abstract excerpt
Soft tissue sarcomas have been examined for alterations in the p53 gene. In six sarcomas, loss or rearrangement of both alleles of this gene was detected while in a further seven sarcomas, point mutation or absence of transcription of the p53 gene was observed. Abnormalities of the p53 gene were...
Topics
- Base Sequence
- Blotting, Southern
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- Exons
- Gene Expression Regulation, Neoplastic
- Gene Rearrangement
- Genes, Retinoblastoma
- Genes, p53
- Homozygote
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Sarcoma
- Soft Tissue Neoplasms
- Transcription, Genetic