Article
Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene.
Oncogene - 1 Sept 1990
Stratton M R, Moss S, Warren W, Patterson H, Clark J, Fisher C, Fletcher C D, Ball A, Thomas M, Gusterson B A
Abstract excerpt
Soft tissue sarcomas have been examined for alterations in the p53 gene. In six sarcomas, loss or rearrangement of both alleles of this gene was detected while in a further seven sarcomas, point mutation or absence of transcription of the p53 gene was observed. Abnormalities of the p53 gene were found in several classes of soft tissue sarcoma, including leiomyosarcomas, rhabdomyosarcomas and malignant fibrous...
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