Molecular genetic considerations in osteosarcoma.

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Article

Molecular genetic considerations in osteosarcoma.

Clinical orthopaedics and related research - 1 Sept 1991

Hansen M F

Abstract excerpt

Osteosarcoma tumorigenesis is consistent with a model by which tumorigenesis results if both alleles at the retinoblastoma susceptibility locus (RBI) are altered. Additional genetic evidence strongly suggests that another obligate event in osteosarcoma tumorigenesis is the homozygous alteration of another gene, p53. Both the RB1 gene and p53 have been proposed to act as tumor-suppressor genes, suggesting that, in...

Topics

Base Sequence
Blotting, Southern
Bone Neoplasms
Causality
Chromosome Deletion
Chromosome Mapping
Gene Amplification
Genes, Retinoblastoma
Genes, Tumor Suppressor
Genes, p53
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Models, Genetic

Molecular Sequence Data

Mutagenesis

Osteosarcoma

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 1679382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1679382-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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