Article
A TP53 mutation detected in cells established from an osteosarcoma, but not in the retinoblastoma of a patient with bilateral retinoblastoma and multiple primary osteosarcomas.
Cancer genetics and cytogenetics - 1 Dec 1992
Hovig E, Andreassen A, Fangan B M, Børresen A L
Abstract excerpt
A patient with bilateral retinoblastoma and subsequent multiple primary osteosarcomas has been described previously. Osteosarcoma cell lines established from this patient were shown to express a shortened RB1 mRNA transcript and no detectable normal Rb protein. We now show that the osteosarcoma c...
Topics
- Base Sequence
- DNA, Neoplasm
- Electrophoresis
- Eye Neoplasms
- Genes, Tumor Suppressor
- Humans
- Infant
- Male
- Molecular Sequence Data
- Mutation
- Neoplasm Proteins
- Neoplasms, Multiple Primary
- Nerve Tissue Proteins
- Osteosarcoma
- Polymerase Chain Reaction
- Retinoblastoma
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53