Article
[Roles of tumor suppressor genes in human osteosarcoma cells].
Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan - 1 Mar 1991
Ohshima T
Abstract excerpt
Inactivation of two tumor suppressor genes, RB and p53, is associated with tumor formation. To elucidate the molecular basis of the tumorigenesis of human osteosarcoma, structural and expressional alterations of these two genes were examined in five human osteosarcoma cell lines, two of which were from Japanese patients. In addition, I analyzed two adenovirus E1A-binding proteins, p107 and p300, putative "tumor...
Topics
- Adenovirus Early Proteins
- Cell Division
- DNA, Neoplasm
- Gene Expression
- Genes, Tumor Suppressor
- Humans
- Mutation
- Oncogene Proteins, Viral
- Osteosarcoma
- RNA, Messenger
- Tumor Cells, Cultured