Article
Elevated p53 RNA expression correlates with incomplete osteogenic differentiation of radiation-induced murine osteosarcomas.
International journal of cancer - 21 Jan 1992
Strauss P G, Mitreiter K, Zitzelsberger H, Luz A, Schmidt J, Erfle V, Höfler H
Abstract excerpt
An important role for the p53 gene in osteogenic sarcomas has been imputed by identification of somatically acquired gene alterations in human osteosarcomas and by the development of osteosarcomas in p53 transgenic mice. To study the involvement of p53 in radiation-induced osteosarcomagenesis, we...
Topics
- Animals
- Biomarkers, Tumor
- Cell Differentiation
- Gene Expression
- Genes, p53
- Mice
- Mice, Inbred BALB C
- Mutation
- Neoplasm Transplantation
- Neoplasms, Radiation-Induced
- Osteocalcin
- Osteosarcoma
- RNA, Neoplasm
- Tumor Cells, Cultured