Article
[A genomewide scan for the susceptibility gene loci to ankylosing spondylitis in Chinese Han population].
Yi chuan xue bao = Acta genetica Sinica - 1 Mar 2004
Gu Ming-Min, Yuan Wen-Tao, Yang Jue-Qin, Zhang Jing, Xiong Xiao-Yan, Yao Fang-Juan, Lu Zhen-Yu, Wang Zhu-Gang, Huang Wei, Fan Li-An
Abstract excerpt
Ankylosing spondylitis (AS) is a common inflammatory arthritis, with a prevalence of 1@1000-3@1000 in Caucasian and 2@1000 in Chinese population. The recognition of the association of HLA-B27 with AS confirmed the importance of heritable factors in the disease. Whole-genome scans showed that some affected-sibling-pair families with AS not only demonstrated strong linkage to the MHC locus, but also identified...
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