Article
Combined analysis of three whole genome linkage scans for Ankylosing Spondylitis.
Rheumatology (Oxford, England) - 1 May 2007
Carter K W, Pluzhnikov A, Timms A E, Miceli-Richard C, Bourgain C, Wordsworth B P, Jean-Pierre H, Cox N J, Palmer L J, Breban M, Reveille J D, Brown M A
Abstract excerpt
OBJECTIVE: Ankylosing spondylitis (AS) is a debilitating chronic inflammatory condition with a high degree of familiality (lambda(s) = 82) and heritability (>90%) that primarily affects spinal and sacroiliac joints. Whole genome scans for linkage to AS phenotypes have been conducted, although results have been inconsistent between studies and all have had modest sample sizes. One potential solution to these...
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