Article
A locus on chromosome 9p predisposes to a specific disease manifestation, acute anterior uveitis, in ankylosing spondylitis, a genetically complex, multisystem, inflammatory disease.
Arthritis and rheumatism - 1 Jan 2005
Martin Tammy M, Zhang Ge, Luo Jingchun, Jin Li, Doyle Trudy M, Rajska Barbara M, Coffman Jessica E, Smith Justine R, Becker Matthias D, Mackensen Friederike, Khan Muhammad A, Levinson Ralph D, Schumacher H Ralph, Wade N Kevin, Rosenbaum James T, Reveille John D
Abstract excerpt
OBJECTIVE: Uveitis or intraocular inflammation is a major cause of visual loss. Acute anterior uveitis (AAU) affects approximately 40% of patients with ankylosing spondylitis (AS) but also affects patients with no evidence of spondylarthritis. We sought to determine whether a unique genetic region could be implicated in a specific manifestation-AAU-of a multisystem, inflammatory, genetically complex disease, AS....
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