Article
Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci.
American journal of human genetics - 1 Apr 2001
Laval S H, Timms A, Edwards S, Bradbury L, Brophy S, Milicic A, Rubin L, Siminovitch K A, Weeks D E, Calin A, Wordsworth B P, Brown M A
Abstract excerpt
Ankylosing spondylitis (AS) is a common inflammatory arthritis predominantly affecting the axial skeleton. Susceptibility to the disease is thought to be oligogenic. To identify the genes involved, we have performed a genomewide scan in 185 families containing 255 affected sibling pairs. Two-point and multipoint nonparametric linkage analysis was performed. Regions were identified showing "suggestive" or stronger...
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