Identification of major loci controlling clinical manifestations of ankylosing spondylitis.

doi:10.1002/art.11106

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Article

Identification of major loci controlling clinical manifestations of ankylosing spondylitis.

Arthritis and rheumatism - 1 Aug 2003

Brown Matthew A, Brophy Sinead, Bradbury Linda, Hamersma Jasmin, Timms Andrew, Laval Steven, Cardon Lon, Calin Andrei, Wordsworth B Paul

Abstract excerpt

OBJECTIVE: To identify genomic regions linked with determinants of age at symptom onset, disease activity, and functional impairment in ankylosing spondylitis (AS). METHODS: A whole genome linkage scan was performed in 188 affected sibling pair families with 454 affected individuals. Traits assessed were age at symptom onset, disease activity assessed by the Bath Ankylosing Spondylitis Disease Activity Index...

Topics

Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 6
Family Health
Genetic Predisposition to Disease
Genome, Human
Genotype
Humans
Lod Score
Spondylitis, Ankylosing

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PMID: 12905477
DOI: 10.1002/art.11106

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