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The genetic basis of ankylosing spondylitis: new insights into disease pathogenesis

1 May 2014

Abstract excerpt

Ankylosing spondylitis (AS) is a complex disease involving multiple risk factors, both genetic and environmental. AS patients are predominantly young men, and the disease is characterized by inflammation and ankylosis, mainly at the cartilage-bone interface and enthesis. HLA-B27 has been known to be the major AS-susceptibility gene for more than 40 years. Despite advances made in the past few years, progress in...

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PMID: 24971029
DOI: 10.2147/tacg.s37325

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