Article
Tissue-specific and imprinted epigenetic modifications of the human NDN gene.
Nucleic acids research - 1 Jan 2004
Lau Jason C Y, Hanel Meredith L, Wevrick Rachel
Abstract excerpt
Allele-specific DNA methylation, histone acetylation and histone methylation are recognized as epigenetic characteristics of imprinted genes and imprinting centers (ICs). These epigenetic modifications are also used to regulate tissue-specific gene expression. Epigenetic differences between alleles can be significant either in the function of the IC or in the cis-acting effect of the IC on 'target' genes...
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