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DNA methylation in genomic imprinting, development, and disease

1 Jan 2001

Abstract excerpt

Changes in DNA methylation profiles are common features of development and in a number of human diseases, such as cancer and imprinting disorders like Beckwith-Wiedemann and Prader-Willi/Angelman syndromes. This suggests that DNA methylation is required for proper gene regulation during development and in differentiated tissues and has clinical relevance. DNA methylation is also involved in X-chromosome...

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PMID: 11568896
DOI: 10.1002/path.890

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