Article
Stochastic loss of silencing of the imprinted Ndn/NDN allele, in a mouse model and humans with prader-willi syndrome, has functional consequences.
PLoS genetics - 1 Jan 2013
Rieusset Anne, Schaller Fabienne, Unmehopa Unga, Matarazzo Valery, Watrin Françoise, Linke Matthias, Georges Beatrice, Bischof Jocelyn, Dijkstra Femke, Bloemsma Monique, Corby Severine, Michel François J, Wevrick Rachel, Zechner Ulrich, Swaab Dick, Dudley Keith, Bezin Laurent, Muscatelli Françoise
Abstract excerpt
Genomic imprinting is a process that causes genes to be expressed from one allele only according to parental origin, the other allele being silent. Diseases can arise when the normally active alleles are not expressed. In this context, low level of expression of the normally silent alleles has been considered as genetic noise although such expression has never been further studied. Prader-Willi Syndrome (PWS) is...
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