Article
Comparative anatomy of chromosomal domains with imprinted and non-imprinted allele-specific DNA methylation.
PLoS genetics - 1 Aug 2013
Paliwal Anupam, Temkin Alexis M, Kerkel Kristi, Yale Alexander, Yotova Iveta, Drost Natalia, Lax Simon, Nhan-Chang Chia-Ling, Powell Charles, Borczuk Alain, Aviv Abraham, Wapner Ronald, Chen Xiaowei, Nagy Peter L, Schork Nicholas, Do Catherine, Torkamani Ali, Tycko Benjamin
Abstract excerpt
Allele-specific DNA methylation (ASM) is well studied in imprinted domains, but this type of epigenetic asymmetry is actually found more commonly at non-imprinted loci, where the ASM is dictated not by parent-of-origin but instead by the local haplotype. We identified loci with strong ASM in human tissues from methylation-sensitive SNP array data. Two index regions (bisulfite PCR amplicons), one between the...
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