Article
Tissue-specific patterns of allelically-skewed DNA methylation.
Epigenetics - 1 Jan 2016
Marzi Sarah J, Meaburn Emma L, Dempster Emma L, Lunnon Katie, Paya-Cano Jose L, Smith Rebecca G, Volta Manuela, Troakes Claire, Schalkwyk Leonard C, Mill Jonathan
Abstract excerpt
While DNA methylation is usually thought to be symmetrical across both alleles, there are some notable exceptions. Genomic imprinting and X chromosome inactivation are two well-studied sources of allele-specific methylation (ASM), but recent research has indicated a more complex pattern in which genotypic variation can be associated with allelically-skewed DNA methylation in cis. Given the known heterogeneity of...
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